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ProteinLIPs identifies and displays highly polar and poorly packed buried interfaces in proteins (LIPs), which constitute preferential locus for protein stability design in non-two-state proteins and may provide hints on protein dynamics and function.

As LIPs are likely the first regions of a protein to become unfolded at high temperatures, stabilizing LIPs is a recommended approach to increase the relevant stability of a non-two-state protein, as illustrated in Lamazares_et_at_(2015).

If you use ProteinLIPs, please cite:

  • García-Cebollada, H., López A., Espinosa-Angarica, V, Galano-Frutos, J. J. & Sancho, J. ProteinLIPs: a web server for identifying highly polar and poorly packed buried interfaces in proteins (submitted for publication).
  • Espinosa-Angarica, V. & Sancho, J. Protein Dynamics Governed by Interfaces of High Polarity and Low Packing Density. PLoS ONE 7, e48212 (2012). DOI: 10.1371/journal.pone.0048212.

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